Advancements in Nanoparticle Biosensors: Applications, Properties, and Considerations for Improving Performance and Detection Capabilities

Abstract

Nanoparticle biosensors have emerged as a powerful diagnostic tool, offering highly sensitive and specific detection of biomarkers and pathogenic agents. This article discusses various applications of nanoparticle biosensors in disease diagnosis and public health monitoring. Magnetic nanoparticles have unique magnetic properties that enable their application in novel separation techniques. This review aims to evaluate the use of magnetic separation across various fields including mineral processing, environmental remediation, and biomedical research. In mineral processing, magnetic separation techniques are commonly employed to separate magnetite from iron ore or other naturally magnetic minerals from gangue material. This allows for an efficient concentration of valuable ore. Similarly, in environmental applications, magnetic nanoparticles can selectively bind to pollutants such as heavy metals in soil and water, permitting separation using an external magnetic field and removal of contaminants. Within biomedical research, magnetic separation has proved a versatile technique for isolating target cells, proteins, and pathogens. Functionalization of magnetic nanoparticles allows specific binding followed by magnetic retrieval. This provides a simple, rapid approach for diagnostic tests, biomarker analysis, and other medical applications. Magnetic separation offers an effective means of differentiating between magnetic and non-magnetic components across many industries and research disciplines.